Document Type

Article

Original Publication Date

2016

Journal/Book/Conference Title

Travel Medicine and Infectious Disease

Volume

14

Issue

5

First Page

464

Last Page

470

DOI of Original Publication

10.1016/j.tmaid.2016.09.008

Comments

Originally published at http://doi.org/10.1016/j.tmaid.2016.09.008.

Date of Submission

January 2017

Abstract

Background: A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.

Methods: Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory, symptoms and tested negative for MERS-CoV on RT-PCR.

Results: None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%).

Conclusions: None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.

Rights

© 2016 Elsevier Ltd. All rights reserved.

Is Part Of

VCU Biostatistics Publications

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