Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine

Authors

William A. KnightFollow
Thomas A. CroppFollow

Document Type

Article

Original Publication Date

2015

Journal/Book/Conference Title

Organic & Biomolecular Chemistry

Volume

13

DOI of Original Publication

10.1039/c5ob00283d

Comments

Originally published at http://dx.doi.org/10.1039/c5ob00283d

Date of Submission

December 2015

Abstract

We report the synthesis and genetic encoding of a recently discovered posttranslational modification, 2-hydroxyisobutryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.

Rights

© Royal Society of Chemistry 2015

Is Part Of

VCU Chemistry Publications