Document Type
Article
Original Publication Date
2011
Journal/Book/Conference Title
Journal of Sensors
Volume
2011
Issue
Article ID 609758, 7 pages
DOI of Original Publication
10.1155/2011/609758
Date of Submission
August 2014
Abstract
The synthesis and characterization of novel N-arylhydroxylamine-based molecular wires are described for use in the site-directed covalent immobilization of whole IgG antibodies onto gold electrode surfaces. The hydroxylamine, electrochemically generated in situ from reduction of the corresponding nitrobenzene, is stable under a wide range of solution conditions and reacts selectively with carbohydrate away from the antibody-binding site to allow the development of immunosensors with maximal activity. Cyclic voltammetric responses have shown a direct correlation between the structure and length of the molecular wire and its stability and concentration at the electrode surface.
Rights
Copyright © 2011 Dwight A. Williams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Is Part Of
VCU Chemistry Publications
Comments
Originally published at http://dx.doi.org/10.1155/2011/609758