Document Type

Article

Original Publication Date

2014

Journal/Book/Conference Title

International Journal of Pharmaceutics

Volume

475

Issue

1-2

First Page

130

Last Page

137

DOI

10.1016/j.ijpharm.2014.08.052

Comments

Originally published at doi:10.1016/j.ijpharm.2014.08.052.

The authors gratefully acknowledge support from the Office of Naval Research from Grant N000140710526.

Date of Submission

April 2015

Abstract

This paper describes the synthesis of H2O2–H2O filled poly(methyl methacrylate) (PMMA) microcapsules as potential candidates for controlled O2 delivery. The microcapsules are prepared by a water-in-oil solvent emulsion and evaporation method. The results of this study describe the effect of process parameters on the characteristics of the microcapsules and on their in vitro performance. The size of the microcapsules, as determined from scanning electron microscopy, ranges from ∼5 to 30 μm and the size distribution is narrow. The microcapsules exhibit an internal morphology with entrapped H2O2–H2O droplets randomly distributed in the PMMA continuous phase. In vitro release studies of 4.5 wt% H2O2-loaded microcapsules show that ∼70% of the H2O2 releases in 24 h. This corresponds to a total O2 production of ∼12 cc/gram of dry microcapsules. Shelf-life studies show that the microcapsules retain ∼84 wt% of the initially loaded H2O2 after nine months storage at 2–8 °C, which is an attractive feature for clinical applications.

Rights

Copyright © 2014 Elsevier B.V. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, [Volume 475, Issues 1–2, 20 November 2014] doi:10.1016/j.ijpharm.2014.08.052.

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