Original Publication Date
Advanced Healthcare Materials
DOI of Original Publication
Date of Submission
Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Hattori, Y., Falgout, L., Lee, W., Jung, S.-Y., Poon, E., Lee, J. W., Na, I., Geisler, A., Sadhwani, D., Zhang, Y., Su, Y., Wang, X., Liu, Z., Xia, J., Cheng, H., Webb, R. C., Bonifas, A. P., Won, P., Jeong, J.-W., Jang, K.-I., Song, Y. M., Nardone, B., Nodzenski, M., Fan, J. A., Huang, Y., West, D. P., Paller, A. S., Alam, M., Yeo, W.-H. and Rogers, J. A. (2014), Multifunctional Skin-Like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing. Advanced Healthcare Materials, 3: 1597–1607. doi: 10.1002/adhm.201400073, which has been published in final form at http://dx.doi.org/10.1002/adhm.201400073. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.
Is Part Of
VCU Mechanical and Nuclear Engineering Publications