DOI
https://doi.org/10.25772/FVQF-EA50
Defense Date
2011
Document Type
Thesis
Degree Name
Master of Science
Department
Biomedical Engineering
First Advisor
Jennifer Wayne
Abstract
The superficial tangential zone (STZ) plays a significant role in normal articular cartilage’s ability to support loads and retain fluids. To date, tissue engineering efforts have not replicated normal STZ function in cartilage repairs. Finite element models were developed to examine the STZ’s role in normal and repaired articular surfaces under different contact conditions. Models were developed by incrementally adding improvements which culminated in contact loading of curved models by permeable and impermeable rigid surfaces and a normal cartilage layer. In the normal STZ, permeability was strain-dependent on volumetric strain; tension-compression nonlinearity modeled collagen behavior. Nonlinear geometry accounted for finite deformation. Results showed that STZ properties of sufficient quality maybe critical for the survival of transplanted constructs in vivo. As compared to rigid surfaces, loading via normal cartilage provided more physiologic results. These models can provide guidance in identifying critical features for the design of tissue engineered articular cartilage constructs.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
May 2011