Defense Date

2012

Document Type

Thesis

Degree Name

Master of Science

Department

Biomedical Engineering

First Advisor

Gary L. Bowlin

Abstract

Bicomponent composite fibers have been widely used in the textile industry and are gaining increasing attention on biomedical applications. In this research, polycaprolactone/poly (lactic acid) side-by-side bicomponent fibers were created for the application of a biodegradable scaffold. The side-by-side structure endowed the fiber with self-crimps when it was processed under certain conditions. This material was produced by electrospinning and collected on a high speed rotating mandrel to get highly oriented fibers. A mechanical stretch at the same direction was done followed by a wet heat treatment for polymer retraction. Crimped fibers were demonstrated by scanning electron microscopy. The quantitative porosity and uniaxial tensile strength was not affected by the post-treatments, but the cell ingrowth and proliferation after seeding the scaffold were significantly improved. In conclusion, the side-by-side crimped material serves as a better extracellular matrix analogue without sacrificing mechanical properties.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

August 2012

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