Defense Date

2012

Document Type

Thesis

Degree Name

Master of Science

Department

Biomedical Engineering

First Advisor

Gerald Miller

Second Advisor

Karla Mossi

Abstract

Real-time, bedside observation of patient clotting is essential in various surgeries in the operating room (OR), but specifically during cardiac surgeries. The objective of this thesis is to design and test a new piezoelectric device that can be used for viscoelasticity measurement with time as a Point of Care (POC) test. Slow turnaround times (TAT) of current methods to monitor blood viscoelastic changes in patients have led to excessive bleeding and the need for blood transfusions in many situations (Despotis et al, 1997). This study shows that the phase shift produced by a resonator sensor can be related to the viscosity of a liquid. By monitoring a phase shift between an actuator and sensor pair, a numeric relationship can be generated and suffice as a calibration curve for each probe. At a calculated error averaging a maximum of 2%, and coefficient of determination and correlation coefficient exceeding 0.95, two probes have been tested in various glycerin solutions and prepared for whole blood experimentation. They have also been tested in varying temperatures to simulate effectiveness in a dynamic environment, similar to that of clotting whole blood.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

August 2012

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