Defense Date

2015

Document Type

Thesis

Degree Name

Master of Science in Dentistry

Department

Periodontics

First Advisor

Parthasarathy Madurantakam DDS,MDS,PHD

Second Advisor

Thomas Waldrop DDS, MS

Third Advisor

John Gunsolley DDS,MS

Abstract

Autologous platelet concentrates represent promising innovative tools in the field of regenerative medicine and are successfully used in oral surgery. Several commercial systems exist that generate various forms of platelet concentrates including Platelet-rich plasma (PRP) and Platelet-rich fibrin (PRF). The alpha- granules of entrapped platelets release a variety of peptide growth factors that promotes healing. Usually PRP is a suspension that can be injected into the site of injury or used as a gel with the addition of thrombin (PRP-gel). In contrast Choukroun’s L-PRF is a dense fibrin based biomaterial enriched with platelets and growth factors. The physical state of these natural biomaterials especially L-PRF permits manual handling and suturing onto the tissue bead to improve healing. However, our knowledge about the mechanical characteristic of L-PRF is quite limited and a good understanding of material properties will enable expansion of current clinical applications. This study demonstrates the techniques to identify L-PRF’s mechanical properties (uniaxial tensile testing and suture retention strength); morphology (scanning electron microscope); biological stability and cytocompatibility.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

4-30-2015

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