The Pineal Gland, via Melatonin, Protects DNA, Coordinates the Endocrine System with the Immune System and Controls the Timing of Reproduction

Author

Craig L. AnthonyFollow

DOI

https://doi.org/10.25772/H8QH-6H51

Defense Date

2001

Document Type

Thesis

Degree Name

Master of Science

Department

Anatomy & Neurobiology

First Advisor

Hugo R. Seibel

Abstract

The pineal gland secretes the hormone melatonin (n-acetyl-5-methoxytryptamine) with a circadian rhythm. This secretion's rhythm becomes disrupted with age. When melatonin secretion is decreased with advanced age, the immune, endocrine and reproductive systems fail to function optimally. Melatonin possesses lipophilic and anti-oxidant properties, providing it with access to nuclei. Melatonin protects the DNA, preventing cancerous mutation. Hippocampal degeneration and age increase and prolong the adrenocortical responses to stress. Melatonin supplementation reduces the prolonged exposure to harmful hormones.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

6-28-2016