DOI
https://doi.org/10.25772/ZRAA-CS67
Defense Date
2016
Document Type
Thesis
Degree Name
Master of Science
Department
Biomedical Engineering
First Advisor
Dr. Daniel Conway
Second Advisor
Dr. Christopher Lemmon
Third Advisor
Dr. Andrei Ivanov
Abstract
Cell proliferation and contact inhibition play a major role in maintaining epithelial cell homeostasis. A hallmark of epithelial cells is strong cell-cell junctions. These junctions include E-Cadherin, a type of adherens junction that is critical for both barrier function and contact inhibition. Prior experiments by other groups have shown that adherens junctions are subject to mechanical tension. Externally applied forces (e.g. stretch) results in changes in E-Cadherin forces that coordinate proliferation. My current work tests the hypothesis that E-Cadherin forces mediate the spatial regulation of cell proliferation even in the absence of externally applied forces.
Rights
© Abhinav Mohan
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
12-17-2016