Author ORCID Identifier

orcid.org/0000-0001-8098-5791

Defense Date

2017

Document Type

Thesis

Degree Name

Master of Science

Department

Human Genetics

First Advisor

Silviu-Alin Bacanu

Abstract

Major Depressive Disorder (MDD) is a complex multifactorial disorder, which would lead to disability. Environmental and genetic factors are involved in MDD etiology. The aim of this project was to identify loci modifying age at onset (AAO) of MDD using survival models after adjusting for Childhood Sexual Abuse (CSA). To achieve this aim, a dataset was made available by the China Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) consortium. The study population had 5,220 controls and 5,282 cases with MDD. We performed two univariate association analyses using Cox Proportional Hazard (Cox PH) models. These two are Full Sample (FS), cases and controls, and only the Case Cohort (CC). No genome-wide significant associations were found in univariate analyses. Subsequent gene set enrichment analysis showed that there were significant enrichments in neurological Gene Ontology terms and some novel non-neural pathways. These findings may allow us to better understand MDD pathology.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

8-3-2017

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