"CHANGES IN SERUM ICAM-1, SERUM VCAM-1, AND SERUM E-SELECTIN CONCENTRAT" by Jeremy Howard Diehl

This work is part of a retrospective collection of 179 electronic theses and dissertations (ETDs) from the VCU Libraries pilot ETD system that were designated as available only to VCU users. Please contact us at libcompass@vcu.edu if you have questions or if you are the author of one of these and would like to release it for online public access.

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Defense Date

2007

DOI

https://doi.org/10.25772/VFCF-5X66

Document Type

Thesis

Degree Name

Master of Science

Department

Periodontics

First Advisor

Dr. Harvey A. Schenkein

Abstract

Cellular adhesion molecules (CAMs) and selectins are cell-surface proteins involved in the binding of cells to the vascular endothelium. Elevated levels of sCAMs and soluble E-selectin (sE-selectin) have been reported in patients with periodontitis. The aim of this study was to determine if periodontal scaling and root planing would influence the serum concentration of sICAM-1, sVCAM-1, and sE-selectin. Twenty-one subjects with chronic periodontitis received scaling and root planing in conjunction with blood serum sample analysis using enzyme-linked immunosorbent assay (ELISA), to determine if periodontal instrumentation results in changes in serum concentrations of sICAM-1, sVCAM-1, and sE-selectin. No change was observed in serum concentration of sICAM-1 or sVCAM-1. However, in a subset of 17 patients a statistically significant change in serum sE-selectin was observed (P < 0.05). This suggests that there is a decrease in endothelial activation following periodontal treatment.

Comments

Part of Retrospective ETD Collection, restricted to VCU only.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

June 2008

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