Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
It has been established that ε-aminocaproic acid (EACA) inhibits the activation of human plasminogen (Ablondi et al., 1959; Alkjaersig, Fletcher, and Sherry, 1959). Because of this observation, this compound has been used extensively to inhibit the pathologically occurring fibrinolytic system in patients. Recently Roberts (1965) reported that another compound, γ-guanidinobutyric acid (GGBA), like EACA, inhibits the lysis of human blood clots. Furthermore, GGBA, unlike EACA, retards the formation of these clots. The present investigation was undertaken to determine whether GGBA inhibits clot formation in the one-stage prothrombin and in the partial thromboplastin time tests. In addition, the ability of GGBA to inhibit clot lysis was tested using blood from a patient showing active fibrinolysis.
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