Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
Some aspects of the radiosensitivity of single human cells have been examined in vitro. So far, all factors which tend to modify sensitivity to x-radiation appear not to modify (or to modify less effectively) the effects upon single cells of high-dE/dx radiation. Whenever the hazards of heavily ionizing radiations are being evaluated, chronic exposure must be considered equivalent to acute exposure, and any attempts to modify the effects of densely ionizing radiations at the cellular level are probably useless. In the case of cultured human cells, the RBE is dependent upon the endpoint because of the differently-shaped survival curves. Thus, for example, the RBE of fast carbon ions for 50% survival is about 6, whereas, it is only about 2 for 1% survival.
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