Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
Oral hypoglycemic drugs now available are of two types. The biguanides, of which phenformin (DBI) is the only one available, increase glucose utilization by muscles. The sulfonylureas, tolbutamide (Orinase), acetohexamide (Dymelor), and chlorpropamide (Diabinese), stimulate the pancreas to produce and release more insulin. All three sulfonylureas have the same effect in responsive patients, but they differ in potency and in duration of action.
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