Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
The histopathological diagnosis of sporotrichosis is briefly reviewed. The primary lesion consists basically of pseudo-epitheliomatous hyperplasia of the epidermis, intra-epidermal micro-abscesses, a non-specific dermal infiltrate and granulomata composed of central micro-abscess surrounded by a zone of histiocytes and multinucleated giant cells. The significance of the asteroid body is discussed. Evidence is presented to support the view that the development of asteroid bodies and the amount of eosinophilic material in these bodies is related to host resistance and that cigar bodies are found in those cases with little or no resistance and in whom the disease disseminates rapidly and wildly. Avenues of research are suggested.
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