Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
I would like to conclude by citing two rather interesting observations we have made. Three-quarters of all the patients in all our surveillance who have allergic reactions to drugs have had peptic ulcer, ulcerative colitis, or neoplastic disease of the gastrointestinal tract. Of these patients, three-quarters of the drugs producing allergic reactions are administered orally. The rates of allergic reactions to individual drugs in patients with gastrointestinal disease as opposed to those without gastrointestinal disease receiving the same medication, are significantly increased. What the impact is of inflammatory gastrointestinal disease 1) upon the absorption of the drug, 2) upon its metabolism, and 3) upon its antigenicity has not been investigated before. But from these studies it is suggested that inflammatory disease of the gastrointestinal tract may be an important factor predisposing patients receiving oral drugs to occurrence of allergic reactions. It has commonly been supposed that patients with autoimmunological disorders, e.g., system lupus erythematous, may have a predisposition to multiple allergic reactions to drugs. In our evaluation of this problem, there is no significant increase in the occurrence of allergic reactions to drugs in these patients.
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