Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
The effect of catecholamines and a beta-adrenergic blocking agent on sodium flux and short-circuit current was evaluated in isolated frog skin. Alpha stimulation (pronethalol plus epinephrine) decreased net sodium flux and short-circuit current to an equivalent degree. Kinetic studies during alpha stimulation demonstrated a decrease in rate coefficient for entry into the skin transporting compartment but no change in the rate coefficient presumed to be related to active transport. Beta stimulation (isoproterenol) produced an equivalent increase in sodium influx and outflux with no change in net flux, and development of non-sodium current. The results suggest opposing effects of alpha- and beta-adrenergic stimulation on sodium permeability, although on different pathways for sodium movement, i.e., alpha stimulation decreases sodium permeability of the epidermal pathways for active transport, and beta stimulation increases permeability to sodium via another pathway. The beta effects may be related to mucous gland stimulation.
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