Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
I have tried to indicate that it is now possible to separate out events occurring at the surface of intestinal absorptive cells. Previous work has shown that intestinal brush borders contain diverse enzymatic activity and that the surface of the intestinal cell is a site for active glucose accumulation. Furthermore, brush border and microvillous membrane preparations now provide direct evidence that intrinsic factor acts at the intestinal cell surface. These studies directly support the concept that a specific receptor for the IF-B₁₂ complex is located on the surface of ileal, but not jejunal absorptive cells. Studies with antibodies against pure preparations of microvillous membranes verify the existence of this receptor and provide an approach to its further localization and characterization.
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