MCV/Q, Medical College of Virginia Quarterly
Orginal Publication Date
1968
Journal Title
MCV/Q, Medical College of Virginia Quarterly
Volume
4
Issue
3
First Page
101
Last Page
106
Abstract
In this paper I will try to show how the proposed intrinsic dilator mechanism may, with due allowance for a variety of modifying factors, underlie the dilator phases of reactive hyperemia, post-exercise hyperemia, hyperemia due to local warmth, autoregulation, vasomotion, inflammation, and shock. These ideas are based on histamine studies (Schayer, 1962, 1963, 1966). However since there is much misunderstanding about histamine, and since the theory can be largely developed without need to identify the dilator, this paper will be presented in two parts. First, interpretation of the above phenomena in terms of intrinsic dilator mechanism will be attempted. Second, evidence supporting histamine as the dilator will be given.
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