Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
The total complex of immune expression is an interplay between nonspecific antimicrobial humoral systems plus specific antibodies and accessory factors. These systems are backstopped by the phagocytic functions of PMNs. If these fail, mononuclear phagocytes respond as a second line of defense to carry out chronic engagements. In addition to a direct activation process by "substrate," macrophages may be activated and mobilized by a lymphocyte-mediated immunologic reaction which probably involves either a "lymphotoxin" and/or a specific antibody cytophilic for macrophages. Immunologically activated lymphocytes appear to be the primary effector cells of anti-tissue (transplantation) cellular immunity, whereas immunologically activated macrophages appear to be the primary effector cells of antibacterial cellular immunity.
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