Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
In addition to its accentuated pattern of rigidity at decreasing ATP/Ca ratios, the hereditary spherocyte poses a special challenge within the splenic pulp because of its shape. In addition to the geometric requirement for deformability, the spleen also poses a challenge to HS cells because of its pH, and probably also the pO₂ within the splenic pulp. Thus, it is suggested that splenectomy is essentially curative in hereditary spherocytosis because it removes an organ with unique anatomic requirements for red cell passage as well as an adverse environment of lower pH and pO₂.
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