Document Type
Article
Original Publication Date
1990
Journal/Book/Conference Title
Antimicrobial Agents and Chemotherapy
Volume
34
Issue
12
First Page
2436
Last Page
2438
DOI of Original Publication
10.1128/AAC.34.12.2436
Date of Submission
November 2015
Abstract
The effects of 15- and 5-ml doses of magnesium-aluminum hydroxide (MAH) and calcium carbonate (CC) antacids, respectively, on the bioavailability of ofloxacin after single oral 400-mg doses of ofloxacin were investigated in a 32-subject, randomized, crossover, open-label study. On four separate occasions, subjects received ofloxacin alone or antacid 24 h before, 2 h before, or 2 h after ofloxacin administration (n = 16 for each antacid). CC administration had no significant effect on the rate and extent of ofloxacin absorption regardless of the timing of antacid administration. A small but significant negative effect of MAH administration 2 h before ofloxacin administration was noted as evidenced by area under the curve and peak concentration in plasma data. Simultaneous administration of ofloxacin with either antacid was not investigated in this study. It appears that MAH and CC antacids in the doses used in this study generally do not interfere in a clinically significant manner with the bioavailability of ofloxacin, provided that an interval of at least 2 h separates the administration of these products.
Rights
Copyright © 1990, American Society for Microbiology
Is Part Of
VCU Pharmacotherapy and Outcomes Science Publications
Comments
Originally published at http://dx.doi.org/10.1128/AAC.34.12.2436. At time of publishing, Gary R. Matzke was at University of Minnesota.