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We present the results of a double-blinded randomized sham-controlled research study of a non-pharmacologic low back pain intervention. Calmare therapy is an neurocutanous electrical stimulation approach for pain management. The intervention group received Calmare therapy and the other received sham. Differences in pain severity and interference scores, pain sensitivity measures and gene expression profiles are reported. Patterns of downregulated gene expression suggest that Calmare may alter proteins involved in pain transduction may have implications for the treatment of other chronic pain conditions.
non-pharmacologic low back pain intervention, Calmare therapy, differential gene expression, pain transduction proteins
Neurosciences | Nursing
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Angela Starkweather, Ph.D., ACNP-BC, CNRN
Amy Heineman, BSN, RN
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