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Abstract

Water-soluble metallic clusters have been used for a number of important applications. One of the most stable clusters is Au25(SG)18, which are negatively charged in solution and highly monodisperse making them ideal for characterization and analysis applications. We present here a new application where these clusters are shown to increase the mean residence time of polyethylene glycol (PEG) molecules within an alpha hemolysin (αHL) nanopore. The effect appears over a range of PEG sizes and ionic strengths. This increases the resolution of the peaks in the single molecule mass spectrometry (SMMS) current blockade distribution and suggests a means for reducing the ionic strength of the nanopore solute in the SMMS protocol.

Publication Date

2014

Subject Major(s)

Physics

Current Academic Year

Senior

Faculty Advisor/Mentor

Joseph Reiner

Sponsorship

Virginia Commonwealth University. Undergraduate Research Opportunities Program

Is Part Of

VCU Undergraduate Research Posters

Rights

© The Author(s)

Enhanced Single Molecule Mass Spectrometry Via Charged Metallic Clusters

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