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Abstract
This study examines the consequences of Alzheimer’s in rat and mice test subjects. The goal is to identify the effects of certain NLRP3 inhibiting drugs and to see if there are any noticeable effects in regards to impeding the pathological development of Alzheimer’s disease. The results are visualized by implementing the immunohistochemical process to identify neurodegeneration in the brain and to assess the expression levels of amyloid beta as an indicator of Alzheimer’s pathology. Other tests are also conducted on these transgenic mice to gauge cognitive functioning levels during the onset of their disease, those being behavior tests, but not limited to the extraction of information on the results of the NLRP3 inhibitor drug trials which aid in adding to the existing database of quantitative data from previous tests. The results of this study play into further understanding of this crippling neurodegenerative disease.
Publication Date
2023
Subject Major(s)
Psychology
Keywords
Alzheimer's, Neurodegeneration, Neuroscience, Amyloid Beta, TAU, Transgenic, NLRP3, Inflammation
Disciplines
Amino Acids, Peptides, and Proteins | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Genetic Phenomena | Lipids | Medical Neurobiology | Neurology | Other Mental and Social Health | Other Psychiatry and Psychology | Pathological Conditions, Signs and Symptoms | Psychological Phenomena and Processes
Current Academic Year
Freshman
Faculty Advisor/Mentor
Dr. Amy Adkins / adkinsae@vcu.edu
Faculty Advisor/Mentor
Tyler Ogden / ogdentp@vcu.edu
Rights
© The Author(s)
Included in
Amino Acids, Peptides, and Proteins Commons, Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Genetic Phenomena Commons, Lipids Commons, Medical Neurobiology Commons, Neurology Commons, Other Mental and Social Health Commons, Other Psychiatry and Psychology Commons, Pathological Conditions, Signs and Symptoms Commons, Psychological Phenomena and Processes Commons