Suggestive Linkage Detected for Blood Pressure Related Traits on 2q and 22q in the Population on the Samoan Islands

Authors

Karolina A. Aberg, Virginia Commonwealth University
Feng Dai, University of Pittsburgh
Satupaitea Viali, Tupua Tamasese Meaole Hospital, Samoa
John Tuitele, Tafuna Family Health Center, American Samoa
Guangyun Sun, University of Cincinnati
Subba R. Indugula, University of Cincinnati
Ranjan Deka, University of Cincinnati
Daniel E. Weeks, University of Pittsburgh
Stephen T. McGarvey, Brown University

Document Type

Article

Original Publication Date

2009

Journal/Book/Conference Title

BMC Medical Genetic s

Volume

10

Issue

107

DOI of Original Publication

10.1186/1471-2350-10-107

Comments

The electronic version of this article is the complete one and can be found online at:http://www.biomedcentral.com/1471-2350/10/107

or doi:10.1186/1471-2350-10-107

Date of Submission

August 2014

Abstract

Background

High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style.

Results

We found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively.

Conclusion

We have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results.

Rights

© 2009 Åberg et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Is Part Of

VCU Biomarker Research and Personalized Medicine Publications