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Patients with malignancies in the central airways often experience significant breathing difficulties due to occlusion of the airways. One common palliative treatment option for this is a stent placement procedure. While patients often experience immediate symptom relief, long term use can result in the formation of granulation tissue, causing restenosis of the airway. The objective of this project is to design and prototype a modification to the Boston Scientific Ultraflex partially-covered stent in order to reduce granulation tissue and maintain airway patency. Deliverables include the detailed design, a working prototype, and supporting data. The main product specifications include effectiveness in reducing granulation, coating adhesion, and stent stability. The final design for this product consists of a paclitaxel-SIBS coating placed at the uncovered ends of the stent by using a dip coating method. This coating was tested in many ways, including for its effectiveness in reducing cell attachment, release kinetics, coating stability, and cytotoxicity. This testing has shown that the SIBS-paclitaxel coating is effective in reducing cell attachment in-vitro, the coating is stably adhered onto the stent in a moving environment, and that paclitaxel is steadily released from the coating. These results are very promising for future in-vivo studies.
biomedical engineering, restenosis, airway, stent, paclitaxel
Biomedical Engineering and Bioengineering | Engineering
Dr. Rebecca Heise
VCU Capstone Design Expo Posters
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