Defense Date


Document Type


Degree Name

Master of Science



First Advisor

Thomas Eissenberg


Potential reduced exposure products (PREPs) are marketed to reduce smoking’s harm, despite little information concerning their effects. This study adapts previously reported clinical laboratory methods used to evaluate combustible PREPs to investigate the acute effects of four non-combustible PREPs (Ariva, Camel Snus, Marlboro Snus, Commit nicotine lozenge) relative to own brand cigarettes, sham smoking, and one combustible PREP that delivers no measurable nicotine (Quest). Twenty-eight smokers participated in 7 Latin-squared ordered, 2.5-hr sessions in which each product was administered twice (60-minute inter-administration interval). Sessions differed by product and were separated by > 48 hours. Plasma nicotine, heart rate, expired air carbon monoxide (CO), and subjective effects were assessed. Relative to own brand, non-combustible PREPs decreased nicotine and CO exposure, did not suppress abstinence symptoms fully, and were less acceptable. These short-term clinical laboratory methods are reliable and provide valuable information concerning non-combustible PREPs for smokers.


© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

March 2009

Included in

Psychology Commons