Defense Date


Document Type


Degree Name

Master of Science


Biomedical Engineering

First Advisor

Ou Bai


We studied Heart Rate Variability (HRV) evolution during therapeutic hypothermia in newborns with hypoxic ischemic encephalopathy (HIE) using spectral analysis. We hypothesized that HRV measures are predictive of neurological outcome in babies with HIE. Non-stationarity in the data causes inaccurate quantification of the spectral power. A modification was proposed to power spectral analysis approach to mitigate the effect of non-stationarity. The modified and the standard approaches were applied to cardiac beat-to-beat intervals of newborns receiving hypothermia treatment. The performance of the approaches in distinguishing the RRi dynamics of two groups of newborns was assessed using area under the receiver operating characteristic (ROC) curve. Our results showed that the modified spectral analysis distinguished the two groups of neonates better than the standard approach. These results may be useful in identifying the deteriorating physiology of the infants receiving hypothermia treatment early in time and strategize alternate interventions for them.


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Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

December 2013