Defense Date


Document Type


Degree Name

Doctor of Philosophy



First Advisor

Alen Docef


In radiation therapy, it is imperative to deliver high doses of radiation to the tumor while reducing radiation to the healthy tissue. Respiratory motion is the most significant source of errors during treatment. Therefore, it is essential to accurately model respiratory motion for precise and effective radiation delivery. Many approaches exist to account for respiratory motion, such as controlled breath hold and respiratory gating, and they have been relatively successful. They still present many drawbacks. Thus, research has been expanded to tumor tracking.

The overall goal of 4D-CT is to predict tumor motion in real time, and this work attempts to move in that direction. The following work addresses both the temporal and the spatial aspects of four-dimensional CT reconstruction. The aims of the paper are to (1) estimate the temporal parameters of 4D models for anatomy deformation using a novel neural network approach and (2) to use intelligently chosen non-uniform, non-separable splines to improve the spatial resolution of the deformation models in image registration.


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