Defense Date


Document Type


Degree Name

Master of Science


Health Related Sciences

First Advisor

Charles Moore


This study was conducted to determine if Mivacurium (Miv) was as effective as Vecuronium (Vec) in attenuating Succinylcholine (Sch)-induced fasciculations with muscle relaxant doses based upon ideal body weight (IBW). A quasi experimental design was used to study 60 patients who were randomly assigned to one of three groups. The two study groups were compared to a control group and each other with regards to the incidence and intensity of fasciculations. Either Vec (0.01 mg/kg (IBW)), Miv (0.02 mg/kg (IBW)), or saline (control) was administered in a double-blinded manner 3 minutes prior an intubating dose of Sch (IBW). Both pretreatment modalities resulted in a significant (p < .05) decrease in the incidence (Vec 40%, Miv 60%) and intensity of fasciculations when compared to saline (90%). No significant differences (p > .05) were found between the two pretreatment groups with regards to the incidence and intensity of fasciculations. It was concluded that Miv 0.02 mg/kg (IBW) attenuated Sch-induced fasciculations with the same efficacy as Vec 0.01 mg/kg (IBW).


Scanned, with permission from the author, from the original print version, which resides in University Archives.


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VCU University Archives

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VCU Theses and Dissertations

Date of Submission


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Nursing Commons