DOI
https://doi.org/10.25772/Y2YV-3110
Defense Date
2016
Document Type
Thesis
Degree Name
Master of Science
Department
Biomedical Engineering
First Advisor
Gerald Miller
Second Advisor
Dianne Pawluk
Third Advisor
Hooman Tafreshi
Abstract
Left ventricular assist devices (LVADs) are an increasingly utilized therapy for end-stage heart failure. Thrombosis within the graft from the pump to the aorta has been documented, but is poorly researched. This study examines the effect of graft geometry, as measured by radius of curvature, bend angle, and diameter, on thrombogenic flow patterns within the graft for a range of flow conditions. It also examines the effect blood properties, including viscosity and density, on these flow patterns. The results indicated that radius of curvature had a powerful effect on thrombogenic flow patterns. Flowrate and bend angle were also influential. The results of this study offer insight on how graft geometry may interact with flow conditions and blood properties to produce regions of stagnation or recirculation within the outflow graft, which may precipitate thrombogenesis and pose a risk to patients.
Rights
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
12-15-2016