Defense Date


Document Type


Degree Name

Master of Science


Biomedical Engineering

First Advisor

Gerald Miller

Second Advisor

Dianne Pawluk

Third Advisor

Hooman Tafreshi


Left ventricular assist devices (LVADs) are an increasingly utilized therapy for end-stage heart failure. Thrombosis within the graft from the pump to the aorta has been documented, but is poorly researched. This study examines the effect of graft geometry, as measured by radius of curvature, bend angle, and diameter, on thrombogenic flow patterns within the graft for a range of flow conditions. It also examines the effect blood properties, including viscosity and density, on these flow patterns. The results indicated that radius of curvature had a powerful effect on thrombogenic flow patterns. Flowrate and bend angle were also influential. The results of this study offer insight on how graft geometry may interact with flow conditions and blood properties to produce regions of stagnation or recirculation within the outflow graft, which may precipitate thrombogenesis and pose a risk to patients.


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