Defense Date

1971

Document Type

Thesis

Degree Name

Master of Science

Department

Biostatistics

First Advisor

Vernon Chinchilli

Abstract

The objectives of this thesis are

1. to provide a comprehensive guide to using Pocock's group sequential method for clinical trials and

2. to show by computer simulations that the group sequential method is appropriate when using the logistic regression model.

In section 1.2, clinical trials are defined with an emphasis on Phase III clinical trials. The primary intent of sections 1.2 and 1.3 is to describe clinical trial characteristics which suggest that interim analyses are desirable. In section 1.4, it is shown that interim analyses should not consist of performing the usual significance tests. Chapter 1, then, describes the basis for the development of the group sequential method.

Chapter 2 describes the group sequential method in detail (objective #1) and chapter 3 includes the results of the Monte Carlo study (objective #2).

Comments

Scanned, with permission from the author, from the original print version, which resides in University Archives.

Rights

© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

2-7-2018

Included in

Biostatistics Commons

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