Defense Date


Document Type


Degree Name

Master of Science in Dentistry



First Advisor

Sinem Esra Sahingur

Second Advisor

Janina Golob Deeb

Third Advisor

Thomas Waldrop


Objectives: The aim of this pilot study was to compare the changes in oral and gut microbiota, endotoxemia, and systemic and local inflammatory markers following oral interventions in subjects with and without cirrhosis.

Methods: Study subjects displaying gingivitis or mild/moderate periodontitis were placed into two groups: with cirrhosis (n= 24) and without cirrhosis (n=21). Each subject received nonsurgical periodontal therapy. Serum, stool and saliva samples were collected prior to and 30 days post-therapy and analyzed for stool/saliva microbiome, MELD score, endotoxin and IL-6 levels.

Results: There was no difference in age, gender and the periodontal disease status between groups. At day 30 post therapy, there was a significant reduction in MELD score, endotoxin levels, IL-6 levels and oral and stool microbiome dysbiosis in cirrhotic patients.

Conclusion: Endotoxemia and systemic inflammation can be reduced following periodontal therapy, which is likely due to improvement in oral-origin microbiota in both saliva and stool in cirrhotic patients.


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Available for download on Saturday, July 15, 2023