Doctor of Philosophy
Dr. Maryanne M. Collinson
Fabrication of nanoporous electrodes for sensing applications
By Md Rezaul Karim Khan, Ph.D.
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.
Virginia Commonwealth University, 2019. Major Director: Dr. Maryanne M. Collinson
Professor of Chemistry
The focus of this dissertation work is the fabrication of nanoporous electrodes and the study of their chemical and physical properties. The fabrication routes involved one or more of the following strategies: dealloying or chemical corrosion, co-electrodeposition, physical vapor deposition, and metal ions reduction. The work was not only restricted to the synthesis of nanoporous electrodes but also extended to its applications. For the first time, we showed the use of nanoporous gold electrodes as a potentially new measurement tool to evaluate the redox potential of red blood cell (RBC) solutions over a 56 day storage period and explored the role that increased concentrations of Vitamin C have on the long-term stability of stored blood. The synthesized cost-effective Au decorated TiN (TiN-Au) nanoporous electrode, prepared by glancing angle deposition technique, performed well for the first time in electroanalytical sensing of common redox molecules such as potassium ferricyanide, dopamine, uric acid (UA), and ascorbic acid (AA). High surface area nanoporous gold electrodes were interfaced to polydimethylsiloxane (PDMS) to create flexible electrodes for electrochemical sensing in samples with a complex matrix. Proof-of-principle was established by measuring uric acid in RBC packets. This flexible nanoporous electrode could be used for the continuous monitoring of redox-active biomolecules in a blood bag or urine bag. We also showed the application of nanoporous gold-based electrodes toward the simultaneous voltammetric redox sensing of UA and AA under biofouling conditions. Electroanalytical chemistry and electrocatalysis served as the heart of this work to study potential applications of the prepared nanoporous materials.
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Available for download on Sunday, November 24, 2024