Defense Date


Document Type


Degree Name

Master of Science in Dentistry



First Advisor

Sinem Esra Sahingur

Second Advisor

Thomas Waldrop

Third Advisor

Zhao Lin


Purpose: To determine the effect of Quercetin, a plant based over the counter flavonoid, on periodontal inflammation in a murine model of periodontitis.

Methods: Periodontitis was induced in age and gender matched mice (C57BL/6) using ligatures on the left side of the maxilla and right side was left un-ligated as baseline control. The animals received daily Quercetin gavage or Phosphate Buffered Saline (PBS) starting 5 days prior to ligation which continued throughout the experimental protocol. Micro-computed tomography (micro CT) imaging was used to determine alveolar bone loss. Real Time quantitative (qRT) PCR was used to determine level of gingival tissue cytokine expression. Hematoxylin and eosin (H&E) staining was used to determine gingival tissue inflammatory cell infiltrate.

Results:There was significantly increased bone loss and cytokine (TNF and IL-6) expression in the ligated sites of both groups of mice compared to un-ligated control sites (p

Conclusion: Quercetin supplement diminishes gingival inflammation. Future studies are warranted to determine the beneficial effect of quercetin improving clinical outcomes in periodontitis patients.


© Sara Holden, DDS

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission


Available for download on Monday, March 10, 2025