Author ORCID Identifier


Defense Date


Document Type


Degree Name

Master of Science in Dentistry



First Advisor

Dr. Garry Myers

Second Advisor

Dr. Caroline Carrico

Third Advisor

Dr. Shawn McMahon



The aim of this retrospective cohort study was to assess the treatment outcome of orthograde perforation repair using bio-ceramic based materials.


Data from the VCU graduate endodontic practice were analyzed retrospectively. Treatment had been conducted by VCU endodontic residents under the supervision of qualified endodontists during the period from August 2014-December 2020. All cases in which a bio-ceramic based material had been used as a perforation repair material were included. Bio-ceramic based materials included MTA, EndoSequence Root Repair Material Putty and Paste (ERRM), and iRoot BP Plus Root Repair Material (BP-RRM). Perforation repair was performed using a dental operating microscope. Two calibrated examiners assessed the radiographic outcome 6 to 24 months after treatment. The relationship between the pre-operative factors and treatment outcome was analyzed using binary logistic regression analysis.


Forty-seven cases were initially identified from August 2014 to December 2020. Of these, 24 cases were examined at follow-up (51% recall rate). Overall, 16 of the included teeth (66%) were classified as healed/healing, and 8 teeth (33%) were classified as non-healing. The results of the binary logistic regression analysis showed that none of the 7-pre-operative variables included in the model were significantly associated with the outcome (p > 0.05).


Based on the binary logistic regression model, newer calcium silicate-based materials, ERRM and BP-RRM, are comparable to the clinical performance of MTA in perforation repair procedures.


© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission


Available for download on Tuesday, May 10, 2022