This work is part of a retrospective collection of 179 electronic theses and dissertations (ETDs) from the VCU Libraries pilot ETD system that were designated as available only to VCU users. Please contact us at if you have questions or if you are the author of one of these and would like to release it for online public access.

Non-VCU users: Please talk to your librarian about requesting this thesis through interlibrary loan.

Defense Date


Document Type


Degree Name

Master of Science



First Advisor

Dr. Harvey A. Schenkein


Balance between matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) is required for normal wound healing. Chronic inflammation, such as that seen in cardiovascular and periodontal diseases, may upset this balance. The aim of this study was to determine whether initial periodontal therapy would have an effect systemically on the levels of MMP-9 and TIMP-1. Twenty-one patients with generalized chronic periodontitis were enrolled in the study. Clinical examinations were conducted and parameters measured. Scaling and root planing was performed and blood analysis done to determine the plasma concentrations of MMP-9 and serum concentrations of TIMP-1. Initial periodontal therapy resulted in improvements in gingival inflammation and plaque levels. No effect on the plasma concentrations of MMP-9 and serum concentrations of TIMP-1 could be found following therapy.


Part of Retrospective ETD Collection, restricted to VCU only.


© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

June 2008