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Defense Date


Document Type


Degree Name

Master of Science



First Advisor

Dr. Ronald Polk


Objective To describe bacterial resistance as rates and proportions, describe the variousmeasures of antibacterial use diversity and to examine any associations that may existbetween diversity and resistance measures.Methods A retrospective, observational study design was used to describe the patterns ofresistance and diversity of antibacterial use from 2002-2005 in a sample of UHC memberhospitals. Relationships between resistance and diversity of antimicrobial use during agiven year and across the study period were also analyzed.Results Different measures of both resistance and diversity are well correlated with oneanother. Significant associations between different measures of diversity and resistanceappear throughout the study period depending on the year and measures used.Conclusions The true pattern, if one exists, between diversity and resistance remains unclear.This study provides evidence for future research of diversity and resistance to determinewhich mix of diversity is most associated with resistance.


Part of Retrospective ETD Collection, restricted to VCU only.


© The Author

Is Part Of

VCU University Archives

Is Part Of

VCU Theses and Dissertations

Date of Submission

June 2008