Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness In Alloreactivity Incidence Following Stem Cell Transplantation

Authors

Vishal Koparde, Virginia Commonwealth University, Center for the Study of Biological ComplexityFollow
Badar Abdul Razzaq, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Tara Suntum, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Roy Sabo, Virginia Commonwealth University, Department of BiostatisticsFollow
Allison Scalora, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Myrna Serrano, Virginia Commonwealth University, Center for the Study of Biological ComplexityFollow
Max Jameson-Lee, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Charles Hall, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
David Kobulnicky, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Nihar Sheth, Virginia Commonwealth University, Center for the Study of Biological ComplexityFollow
Juliana Feltz, Virginia Commonwealth University, Center for the Study of Biological Complexity
Daniel Contaifer, Virginia Commonwealth University, School of PharmacyFollow
Dayanjan Wijesinghe, Virginia Commonwealth University, School of PharmacyFollow
Jason Reed, Virginia Commonwealth University, Department of PhysicsFollow
Catherine Roberts, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow
Rehan Qayyum, Section of Hospital Medicine, Department of Internal MedicineFollow
Gregory Buck, Virginia Commonwealth University, Center for the Study of Biological ComplexityFollow
Michael Neale, Virginia Commonwealth University, Department of Psychiatry and Statistical GenomicsFollow
Amir Toor, Virginia Commonwealth University, Bone Marrow Transplant Program, Department of Internal MedicineFollow

Document Type

Dataset

DOI

doi:10.21974/V4Z031

Publication Date

2017

Abstract

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p

Funders

NIH-NCI Cancer Center Support Grant; Virginia’s Commonwealth Health Research Board Grant

Grant Number

P30- CA016059 (PI: Gordon Ginder, MD); CHRB #236-11-13 (PI: Michael Neale, PhD)

Language

English

Is Part Of

VCU Massey Cancer Center Data

Date of Submission

10-19-2017