Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
During a study of the effects of a series of guanidine compounds on the esterolytic activities of thrombin, plasmin, and streptokinase plus plasmin or plasminogen, it was found that one of these compunds, γ-guanidinobutyric acid (GGBA), acted in several ways like ε-aminocaproic acid (EACA). Neither compound had any inhibiting effects on the rate of hydrolysis of TAMe (p-toluenesulfonyl-L-arginine methyl ester), but both inhibited the activation of plasminogen by streptokinase. EACA was the more potent inhibitor. Since EACA has been shown to inhibit the lysis of fibrin, primarily because it inhibits the activation of plasminogen (Ablondi et al., 1959, Alkjaersig, Fletcher, and Sherry, 1959), GGBA was tested to see if it, too, would inhibit the lysis of blood clots. It was found to do so. In addition, it was found that GGBA also inhibits the formation of blood clots, which EACA does not do. These preliminary results are reported here.
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