Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
A number of observations in the last few years have attracted attention to the possibility of viral infection in systemic lupus erythematosus (SLE). One of these is the occurrence of interwoven tubular structures, usually in the endothelial cells of the kidney but also in the lymphocytes and in fibroblasts when SLE skin fibroblasts are cultured. These tubular structures have resembled viruses (they were thought by their discoverers to be myxo- or paramyxoviruses), but it has been argued that they are not viruses because of their size and appearance and because they have been produced in tissue cultures from subjects who do not have SLE; they occur in many other conditions which are not related to SLE.
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