Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
In previous work with rabbits on high-cholesterol and on high-cholesterol plus triparanol diets, I observed that no offspring were produced, even though the animals were not carefully separated by sex. Consequently, it seemed advisable, as the main purpose, to reexamine the possibility that a diet high in cholesterol, with or without triparanol, might affect reproduction. In this study rats were used instead of rabbits. Since triparanol inhibits the conversion of desmosterol to cholesterol, it seemed advisable to study the effect of triparanol on blood and tissue cholesterol itself. It also seemed of interest to study the distribution of cholesterol in various tissues.
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