Orginal Publication Date
MCV/Q, Medical College of Virginia Quarterly
Isolated organ perfusion provides us with an excellent tool for investigating the physiology and the function of a variety of individual organs. It enables us to explore these organs, their pharmacologic reactions, their ability to withstand various stresses, their pathology after stress and their suitability for preservation and transplantation. Isolated perfusion has allowed us to better understand hemodynamics, effects of various perfusates, and toxicity of drugs on individual organs. We have recently been enlightened about the vital role of platelets and endothelial integrity. We now have a model for assessing individual hormonal systems and qualitative and quantitative endocrine and exocrine functions. Organ perfusion has provided us with a method for preservation and a means for studying organ viability prior to transplantation. We now have an invaluable isolated system in which we can study certain aspects of immunology, including the rejection mechanism, sensitization, and the evaluation of serum and cell-bound phenomena. Our immediate goals include detection of cell or organ death prior to reimplantation by some rapid and accurate method and prolongation of preservation time for in vitro organ systems.
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