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MCV/Q, Medical College of Virginia Quarterly
Our interest in the problem of tolerance induction is directly concerned with clinical organ transplantation. ALS is highly effective in depressing cellular immunities. Since at least initial allograft rejection is predominantly a cellular phenomenon, one would expect ALS to be highly effective clinically. Our initial observations in this regard support this concept. However, non-specific depression of cellular immunity may also lead to an increased number or viral, fungal, and protozoan infections. Experiments, such as these presented, strongly suggest that a specific state of tolerance to organ grafts in man should be attainable with the aid of ALS followed by introduction of appropriate antigen.
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