MCV/Q, Medical College of Virginia Quarterly
Orginal Publication Date
1972
Journal Title
MCV/Q, Medical College of Virginia Quarterly
Volume
8
Issue
3
First Page
221
Last Page
224
Abstract
The role of hemoglobin as a carrier of oxygen in the blood was established in 1859 by Hoppe-Seyler. Bert, using whole blood, furnished experimental data whereby an oxyhemoglobin affinity curve could be plotted. In 1886, C. Bohr published data on purified hemoglobin for the second curve of oxyhemoglobin affinity. By 1903, Bohr had established that the oxyhemoglobin affinity curve was S-shaped for both whole blood and hemoglobin in solution. Since that time, various methods have been reported, or modifications thereof, to estimate oxyhemoglobin affinity.
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