Document Type

Article Presentation

Original Publication Date


Date of Submission

July 2021


Despite the relatively-low prevalence of Herpes Simplex Encephalitis (HSE), it is among the most fatal forms of brain inflammation. In the present study, Pruss et al. seeks to determine the presence of and quantify the specific immunity towards the N-Methyl-D-Aspartate receptor (NMDAR), a synaptic protein, in serum and CSF from patients diagnosed with HSE through PCR techniques. The results showed that up to 30% of patients with HSE also developed anti-NMDAR immunity, demonstrating the presence of a causal relationship. The underlying reason for this association remains unclear.


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