Document Type

Article Presentation

Original Publication Date


Date of Submission

September 2021


Xu et al summarizes some of the different functions of NK cells, focusing on their ability to secrete cytokines and trigger cancer cell cytotoxicity. NK cells have activating and inhibiting receptors on its cell surface, contributing to the balance of stimulating and suppressing signals for NK cells. In the tumor microenvironment, the receptors on the NK cell surface are altered, contributing to NK dysfunction. Immunotherapies have been developed to target increased NK surface inhibitory receptors and have shown promise. However, there is also evidence that regulatory T cell targeting and ADO mediation may also contribute to NK cell cytotoxicity. Further studies should be conducted to investigate the efficacy of NK cell immunotherapies and other methodologies of increasing NK cell antitumor cytotoxicity.


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